“THE BIG ONES”

No. 22 Clemson Tigers at No. 1 Florida State Seminoles

Saturday, 8 p.m. ET, ABC

If you bet on college football picking Clemson +15 vs a Florida State team without star quarterback Jameis Winston for the whole game now would be the best pick of the week. Starting a quarter back with a 2-2 touchdown to interception ratio will let Clemson get an early lead and hold on to it for the whole game.

Pick: Clemson

No. 5 Auburn Tigers at No. 20 Kansas State Wildcats

Thursday at 7:30 p.m. ET, ESPN/WatchESPN

This is one of the best Thursday night matchups in a while and while Bill Snyder is the master of the underdog I think Auburn, the most underrated team in the country will make a statement on national TV.

Pick: Auburn

 Florida Gators at No. 3 Alabama Crimson Tide

Saturday at 3:30 p.m. ET, CBS

Florida had to eek out a triple overtime win over KENTUCKY!  On the other hand the Tide have destroyed every opponent in their path. The homefield advantage and the coaching prowess of Nick Saban give the Edge to bama.

Pick: Alabama

No. 4 Oklahoma Sooners at West Virginia Mountaineers

Saturday at 7:30 p.m. ET, FOX

West Virginia, who gave Alabama a run for their money in week 1 has been a surprise. Going 2-1. But Oklahoma might just be the most complete team in the nation

Pick: Oklahoma

OTHER NOTABLE GAMES

Mississippi State Bulldogs at No. 8 LSU Tigers 

Saturday at 7 p.m. ET, ESPN/WatchESPN

Pick: LSU

No. 2 Oregon Ducks at Washington State Cougars

Saturday at 10:30 p.m. ET, ESPN/WatchESPN

Pick: Oregon

 Bowling Green Falcons at No. 19 Wisconsin Badgers

Saturday at noon ET, ESPN2/WatchESPN

Pick: Wisconsin

 Northern Illinois Huskies at Arkansas Razorbacks

Saturday at 7 p.m. ET, ESPNU/WatchESPN

Pick: Arkansas

 UNLV Rebels at Houston Cougars

Saturday at 8 p.m. ET, ESPN3

Pick: Houston

 Louisiana-Lafayette Ragin’ Cajuns at Boise State Broncos

Saturday at 10:30 p.m. ET, CBS Sports Network

Pick: Boise State